Nikolaus Grigorieff

Nikolaus Grigorieff is a Professor at UMass Chan Medical School, affiliated with the RNA Therapeutics Institute and multiple departments across T.H. Chan School of Medicine and Morningside Graduate School of Biomedical Sciences. His primary role is in structural biology and cryo-electron microscopy (Cryo-EM).

Education: PhD from the University of Bristol, United Kingdom.

Research Interests: Dr. Grigorieff specializes in advancing Cryo-EM methodologies to study biological macromolecules and viruses. His work focuses on high-resolution structural analysis, sample preparation optimization, and computational tools for image processing. Key areas include viral protein structures, ribosome maturation, and cellular component localization. His innovations in software (e.g., Frealign, CTFFIND) and techniques like 2D template matching have revolutionized structural biology.

Publications: His recent work emphasizes Cryo-EM applications in studying viral entry mechanisms, ribosomal assembly intermediates, and optimizing imaging parameters. Themes include improving data quality through defocus correction, minimizing radiation damage, and developing algorithms for particle detection.

Awards: No specific awards listed in the provided text.

Advising/Grants: Collaborates extensively with teams in virology, biochemistry, and computational biology. Leads projects supported by grants focused on Cryo-EM infrastructure and structural biology applications. Advising details not explicitly stated.

Labs/Teams: Core member of the RNA Therapeutics Institute, contributing to interdisciplinary research integrating structural biology with biomedical applications.