معرفی
Dr. Nikki Copeland is a Senior Lecturer in Biomedicine and Director of Studies in Biomedical Science at Lancaster University's Faculty of Health and Medicine. She leads research on DNA replication mechanisms in mammalian cells, focusing on cancer-related mutations and genome instability. Her work explores replication licensing, initiation processes, and differences between cancerous and normal tissues to identify therapeutic targets.
Her research employs cell-based and cell-free DNA replication techniques to study regulatory steps in replication. Key projects include analyzing CIZ1's role in cell cycle regulation and Ap4A's impact on DNA replication under stress. She has supervised students such as Megan Fraser and Hend Abdelrady Mohamed Abdelmohsen on topics ranging from 3D cell models to biomaterials in drug delivery.
Recent publications (2024) highlight structural analyses of viral RNA modifications and CIZ1's regulation of G1 phase length. Earlier work (2011-2020) addressed Ap4A signaling, CRISPR mutation detection, and NUDT2's role in immune response modulation.
Dr. Copeland's lab focuses on cancer biology and genome stability, collaborating with interdisciplinary teams on biomaterials and drug delivery systems. Her research has implications for developing targeted cancer therapies and diagnostic tools.
