معرفی
Nicolas Védrenne serves as an Associate Professor in Toxicology and Environmental Health at the Faculty of Pharmacy, University of Limoges, and is affiliated with Inserm UMR 1248 (Pharmacology and Transplantation). His research office is located in the CBRS building (2nd floor, university side, office 235) at the Limoges campus.
His educational background includes:
- PhD in Neuroscience (2013), University of Limoges, focusing on astrocyte populations in CNS injury repair
- Master’s in Cellular/Molecular Biology & Genetics (2010), University of Poitiers, specializing in stem cells
- Bachelor’s in Cellular Biology & Genetics (2008), University of Poitiers
- University Diploma in Animal Experimentation Level 1 (2012), University of Paris Descartes
Dr. Védrenne pioneers microphysiological systems research, developing innovative Organ-on-a-Chip platforms to model human organ functions and drug interactions. His work integrates microfluidics to simulate physiological flows (blood/urine), advancing personalized medicine through pharmacokinetic modeling while adhering to the 3Rs principle (Replacement, Reduction, Refinement) for animal testing alternatives. Key innovations include proximal tubule-on-a-chip systems for studying drug membrane transporters and xenobiotic toxicity.
His research drives interdisciplinary collaborations across microfabrication, biomaterials, and cell biology to create human-relevant models that overcome limitations of animal studies. Current work focuses on multi-organ signaling (liver-kidney interactions) using microphysiological systems, with applications in drug toxicity screening and therapeutic development.
As an educator, he teaches toxicology across pharmacy programs (Years 3-5), Health Sciences, and Pharmacy Technician preparation courses, covering toxicovigilance, regulatory toxicology, addictionology, and environmental health. His laboratory work within the CBRS facility emphasizes translational research bridging fundamental toxicology with clinical applications.
