معرفی
Nicolas Guillot is an Assistant Professor in the Biosciences Department at INSA Lyon, where he also serves as deputy director of the department and director of the Animal Facility. His academic journey began with a PhD in vascular biology from University Lyon 1 in 2008, followed by postdoctoral training in New York City focusing on vascular inflammation and angiogenesis in sickle cell disease.
- Institution: INSA Lyon
- Department: Biosciences
- Position: Assistant Professor
- Leadership Roles: Deputy Director of Biosciences Department, Director of Animal Facility
His research centers on vascular biology, particularly the endothelial response to mechanical stress and red blood cell-endothelium interactions in sickle cell disease. He also investigates blood rheology, vascular inflammation, and the impact of metabolic conditions on vascular function. His work has important implications for understanding thrombosis, microvascular complications, and cardiovascular pathologies in chronic diseases.
The trends in his recent publications (2016–2025) reveal a consistent focus on vascular and hematological pathologies, particularly sickle cell disease, blood viscosity, microvascular dysfunction, and related conditions such as diabetes and CKD. His collaborative, interdisciplinary research spans physiology, hematology, cardiology, and molecular biology, often involving international teams and appearing in high-impact journals like The Lancet Regional Health - Americas, Blood, and Frontiers in Physiology.
Nicolas Guillot has made significant contributions to understanding:
- The role of omega-3 fatty acids in reducing platelet activity and thrombosis risk
- The involvement of the TGFbeta/BAMBI pathway in vascular restenosis and angiogenesis
- How shear forces alter endothelial lipid metabolism
- Increased vascular risk in diabetic patients with sickle-cell trait
He teaches cardiovascular physiology and pharmacokinetics and leads research supported by multiple grants, collaborating with institutions in the USA, Germany, and the UK. He supervises research within the [VBRBC] team at INSA Lyon and oversees animal research facilities, ensuring ethical and scientific rigor in experimental models.
