معرفی
Nicolas DELSUC is a CNRS Researcher at the BioMolecules Laboratory (UMR 7203 CNRS-SU-ENS) affiliated with École Normale Supérieure in Paris, where he also served as Assistant Professor associate from 2020-2022. His research focuses on the intersection of chemistry, biology, and medicine, developing innovative metal-based compounds for biomedical applications.
His educational background includes:
- M.Sc. in Organic Chemistry, Bordeaux1 University (2005-2007)
- PhD in Organic Chemistry, Bordeaux1 University under Dr. Ivan Huc (2004-2007), focusing on proteomimetic tertiary structures with aromatic oligoamide foldamers
- Post-doctoral fellowship with Prof. Itaru Hamachi at Kyoto University (2007-2009), funded by JSPS
Delsuc's research centers on developing peptidyl metal complexes that mimic metalloenzymes and creating metal-centered probes for bio-imaging and diagnostic applications. His work combines peptide chemistry with inorganic chemistry to create compounds that leverage the properties of both molecular classes. He has made significant contributions to superoxide dismutase (SOD) mimics and catalase mimics, exploring their potential as therapeutic agents for inflammatory diseases and oxidative stress-related conditions.
His recent publications reveal a strong focus on bioinorganic chemistry with emphasis on metalloprobes for cellular imaging, particularly using X-ray fluorescence and IR imaging techniques. His work spans from fundamental inorganic chemistry (spin crossover properties, metal complex speciation) to applied biomedical research (SOD mimics for inflammatory bowel disease, antibacterial photodynamic therapy). The interdisciplinary nature of his research bridges chemistry, biology, and medicine.
His scientific recognition includes:
- ITMO PCSI grant (2024)
- Arc Foundation grant (2023)
- ANR JCJC grant (2016)
- JSPS Postdoctoral Fellowship (2007)
Delsuc has demonstrated strong mentorship through his supervision of numerous PhD students and postdoctoral researchers. His research program has been supported by competitive grants from major French funding agencies. He leads collaborative projects that bring together chemists, biologists, and medical researchers to develop innovative solutions for biomedical challenges, particularly in the areas of oxidative stress and inflammation.
He is part of the Inorganic Cellular Chemistry group within Team 1 at the BioMolecules Laboratory, where he collaborates closely with Prof. Clotilde Policar. His laboratory work focuses on synthesizing and characterizing peptidyl metal complexes, evaluating their biological activity, and developing imaging techniques to track these compounds in cellular systems.
