معرفی
Nels C. Elde is Professor of Human Genetics and Adjunct Professor of Biological Sciences at the University of Utah, where he leads research at the intersection of evolutionary biology and host-pathogen dynamics. His work focuses on genetic conflicts driving rapid adaptation in virus-host systems, with emphasis on molecular mimicry and arms races as evolutionary engines.
His educational background includes:
- B.A. from Carleton College
- Ph.D. from the University of Chicago
Elde's research program investigates how host-pathogen interfaces serve as crucibles for evolutionary innovation. Using primate cell lines and poxviruses as model systems, his lab explores viral mimicry of host proteins (e.g., PKR substrates), genomic structural variations like 'genomic accordions' enabling rapid viral adaptation, and Red Queen dynamics in immunity factors such as OAS-RNase L. Key methodologies integrate phylogenetic analysis with experimental evolution of vaccinia virus to track real-time adaptations including host switching.
Analysis of his 2022-2025 publications reveals dominant themes in viral evasion mechanisms across diverse pathogens—from coronaviruses to Cryptococcus neoformans—with recurring emphasis on evolutionary constraints, structural mimicry, and innate immune pathway coevolution. His work increasingly bridges virology, structural biology, and glycobiology to dissect non-canonical host-microbe interfaces.
Elde actively mentors graduate students in the Molecular Biology Program and postdoctoral researchers, supported by NIH-funded grants examining experimental evolution of host-pathogen conflicts. His laboratory combines deep genome sequencing, recombinant virology, and cross-species cell culture systems to probe adaptation mechanisms.
He directs a research team investigating evolutionary cell biology at the University of Utah and co-hosts the science podcast This Week in Evolution, which analyzes current developments in evolutionary virology and host adaptation for broad scientific audiences.
