Nathalie Boddaert

Prof. Nathalie Boddaert is the Head of the Pediatric Radiology Department at the Necker-Enfants Malades Hospital, leading a team specializing in advanced multimodal neuroimaging techniques. Her work focuses on cerebral blood flow assessment using arterial spin labeling (ASL), structural MRI, diffusion tensor imaging (DTI), and functional MRI (fMRI), with applications in pediatric neurological disorders. The team's research investigates biomarkers for diseases such as tuberous sclerosis, mitochondrial disorders, and brain tumors, emphasizing longitudinal studies and clinical correlations.

Research interests include translational neuroimaging, pediatric epilepsy, and neuro-oncology, with a particular focus on identifying imaging signatures for early diagnosis and monitoring treatment responses. The Image@Imagine research team collaborates on developing MRI protocols to study brain development, vascular anomalies, and rare genetic syndromes.

Publications highlight advancements in neuroimaging applications for pediatric populations, including studies on cerebral perfusion in neonatal stroke, functional reorganization after hemispherotomy, and radiogenomic correlations in diffuse intrinsic pontine gliomas (DIPGs). The team also explores sensorimotor adaptations in deaf children and brain abnormalities in mastocytosis.

Key collaborations involve machine learning integration for diagnostic support and clinical genetics consultations to improve diagnostic rates in complex pediatric cases. Ongoing projects aim to refine non-invasive neuroimaging tools for precision medicine applications in pediatric neurology and oncology.