معرفی
Professor Miguel Constância is a Principal Investigator at the Institute of Metabolic Science (Metabolic Research Laboratories) and the MRC Metabolic Diseases Unit, University of Cambridge, affiliated with the Department of Obstetrics and Gynaecology. He leads research in developmental epigenetics and mentors students and postdoctoral researchers.
His research focuses on three core areas:
- Epigenetics, growth and metabolism: Investigating imprinted genes in placental development, fetal growth, and metabolic regulation using genetically engineered mouse models.
- Epigenetics and gene-environment interactions: Studying how sub-optimal early nutrition induces epigenetic changes increasing diabetes and obesity risk through (epi)genomic screens in rodent and human tissues.
- Inter-organ communication during pregnancy and lactation: Deciphering placental signaling mechanisms and insulin resistance using transgenic tools to track biotin-labeled proteins in maternal-fetal systems.
Professor Constância mentors PhD students Cherlyn Tan (co-supervised with Dr. Russell Hamilton) and Tiago Morais (co-supervised with Prof. Mariana Monteiro), along with MPhil student Zhu Hongyu. His research is funded by the Medical Research Council (MRC), supporting work with genetically engineered models and multi-omics approaches.
His laboratory operates within the Institute of Metabolic Science, utilizing core facilities including the Core Biochemical Assay Lab (CBAL), Core Metabolomics and Lipidomics Laboratory (CMaLL), and Genomics Bioinformatics Core (GBC), while collaborating across the Cambridge Metabolism network.
