معرفی
Michel DuPage is an Assistant Professor of Immunology and Molecular Medicine at the University of California, Berkeley, leading the DuPage Lab. His research focuses on understanding regulatory T cells (T regs ) and their role in cancer immunotherapy and autoimmunity. He investigates epigenetic mechanisms, such as EZH2 and histone modifications, to reprogram T regs for therapeutic purposes. His lab pioneers genetically engineered mouse (GEM) models to study tumor-immune interactions, emphasizing tumor-specific neo-antigens and immune tolerance.
Research interests include T cell plasticity, chromatin regulation in immune cells, and leveraging genetic tools to dissect tumor immunity. The lab’s work bridges cancer biology, immunology, and epigenetics to enhance anti-tumor immunity while minimizing autoimmune toxicity. Key contributions include identifying EZH2 as a critical regulator of T reg stability and demonstrating the therapeutic potential of targeting this pathway in cancer.
Students and lab members include Jesse Garcia Castillo (PhD graduate), Jenna Vickery (MCB graduate student), and Stephen Lin (Biotechnology master’s student). The lab is located in Weill Hall, UC Berkeley, with an office in 441A LSA.
