Michael J Spinella

Michael J Spinella is a Professor at the University of Illinois, affiliated with the Department of Comparative Biosciences. His research focuses on

• Epigenetic mechanisms in cancer
• Testicular and breast cancer biology
• Retinoic acid signaling
• Chemotherapy resistance
• Nuclear receptor regulation

Recent research trends include studies on perfluoroalkyl substances (PFAS) and their impact on cancer progression, epigenetic therapy for testicular germ cell tumors, and G0S2 gene functions in breast cancer. Key collaborations include work with Dr. Zeynep Madak Erdogan and Dr. Rajeev Singh.

His laboratory investigates epigenetic remodeling in chemoresistant tumors and histone demethylase targeting as a strategy to restore chemotherapy sensitivity. Current projects also explore environmental endocrine disruptors in kidney disease and novel therapeutic approaches for cancers via DNA methyltransferase inhibitors.