معرفی
Meru J. Sadhu is a Stadtman Investigator and Section Head of the Systems Biology and Genome Engineering Section at the National Human Genome Research Institute (NIH). He earned his B.S. from California Institute of Technology and Ph.D. from University of California at Berkeley, followed by postdoctoral work in Leonid Kruglyak's lab at UCLA.
- NIH Stadtman Investigator (2018-present)
- Head, Systems Biology and Genome Engineering Section
- Former postdoc in Quantitative Genetics (UCLA)
His research systematically investigates genetic-phenotypic relationships through CRISPR-based methods, yeast models, and high-throughput functional assays. Key areas include:
- Deciphering natural genetic variation
- Engineering synthetic genetic changes
- Developing parallel variant analysis strategies
- Exploring evolutionary constraints in yeast
Recent work demonstrates CRISPR-enabled discovery of essential domains in anti-CRISPR proteins (2024) and characterization of yeast defense mechanisms against killer toxins (2023). Publications span Science, PNAS, and Nature Genetics, with focus on:
- CRISPR-Cas9 functional analysis
- Protein abundance regulation
- Glycolytic pathway evolution
- Genome-wide variant mapping
Awards include:
- NIH Stadtman Investigator (2018)
The section has trained multiple postdoctoral and postbaccalaureate fellows who have transitioned to prestigious academic and industry positions. Current work expands CRISPR applications to address fundamental questions in genetic architecture and evolutionary biology.
