Meredith Jackrel

Meredith Jackrel is an Associate Professor of Chemistry at Washington University in St. Louis, with a laboratory focused on protein misfolding and neurodegenerative diseases. She holds a PhD from Yale University and a BS from The College of New Jersey.

Her research explores protein disaggregases like Hsp104, aiming to understand mechanisms of amyloid disassembly and engineer enzymes to combat diseases such as ALS and Parkinson’s. Key areas include protein engineering, directed evolution, and model systems including yeast, C. elegans, and human-derived neurons.

• Educations: PhD (Yale University), BS (The College of New Jersey)
• Labs: Laboratory Website at Washington University

Her work bridges biochemistry and medicine, with collaborations at the Washington University School of Medicine. Recent NIH-funded research investigates Matrin-3’s role in ALS/FTD and optimizes Hsp104 variants for therapeutic use.

• Awards: NIH MIRA, American Heart Association grants, Frick ALS Laureate

Advisees include graduate researchers Macy Sprunger and Jeremy Ryan. Research extends to pure protein biochemistry, structural biology, and yeast models to dissect amyloid mechanisms.