معرفی
Mengfei Xiong serves as a Visiting Researcher in the Department of Medicinal Chemistry at Uppsala University, specializing in translational PET imaging for neurodegenerative disorders. Their work bridges preclinical research and clinical applications through the development and validation of molecular imaging probes targeting Alzheimer's and Parkinson's disease pathologies.
Key research interests include:
- PET radioligand development for synaptic density and protein aggregates
- Antibody-based therapeutics for brain disorders
- Pharmacokinetics of biologics across the blood-brain barrier
- In vivo validation of imaging probes in rodent and human studies
- Methodological advancements in affinity measurement techniques
Analysis of recent publications reveals a cohesive research trajectory focused on overcoming translational challenges in neuroimaging. Xiong's work consistently addresses critical questions about target engagement, radioligand specificity, and the interplay between therapeutic antibodies and imaging probes, with significant contributions to synaptic density quantification and alpha-synuclein pathology assessment.
Within Uppsala University's Department of Medicinal Chemistry, Xiong collaborates with the Translational PET Imaging group to advance preclinical imaging methodologies and support drug development pipelines for neurodegenerative conditions through rigorous in vivo validation studies.
