معرفی
Dr. Melissa Runge-Morris is a Professor of Pharmacology and Director of the Institute of Environmental Health Sciences (IEHS) at Wayne State University. Her research investigates sulfotransferase enzymes regulating drug/xenobiotic metabolism and their roles in cancer development. Key focuses include transcriptional control of sulfotransferase genes in liver/intestine, developmental expression patterns, and implications for hormone-responsive cancers (e.g., breast/prostate).
Her lab employs molecular, biochemical, and cell-based models (e.g., LS180 colorectal cells, primary hepatocytes) to study enzyme regulation by nuclear receptors (PPARγ, VDR). Recent publications explore sulfotransferase ontogeny, environmental estrogen detoxification, and bile acid conjugation.
Scientific Awards:
- Director, Institute of Environmental Health Sciences (IEHS)
Research Trends: Analysis of her 15 most recent articles reveals sustained focus on sulfotransferase isoform regulation (SULT1C/2A families), developmental toxicology, and enzyme roles in chemical carcinogenesis. Techniques include transcript variant characterization, promoter analysis, and metabolic profiling.
