Matthew S. Simon

Matthew S. Simon, M.D., M.S. is a Clinical Associate Professor at Weill Cornell Medical College, affiliated with the Division of Infectious Diseases and the Department of Population Health Sciences. He serves as the Chief Hospital Epidemiologist at New York-Presbyterian Hospital/Weill Cornell and Deputy Medical Director for Infection Prevention & Control at NewYork-Presbyterian.

• Education: M.Sc. (Weill Cornell, 2013), M.D. (Albert Einstein College, 2006), B.A. (University of Pennsylvania, 2002)
• Certifications: Board-certified in Internal Medicine and Infectious Diseases (American Board of Internal Medicine)

Dr. Simon’s research focuses on healthcare-associated infections, antimicrobial stewardship, and cost-effectiveness analysis of infectious disease interventions. His recent work explores SARS-CoV-2 viral load dynamics, device-associated infections, and machine learning applications in antimicrobial resistance prediction.

Key awards include the Faculty Excellence Award (2025) and Infectious Diseases Society of America Fellowship (2023). His publications span topics including procalcitonin diagnostics, C. difficile prevention, and environmental disinfection.

• Leadership Roles: Former Infectious Diseases Fellowship Program Director (2020-2024), Physician Leader for Antimicrobial Stewardship Program at NYP Hospital
• Expertise: Infection prevention, antimicrobial policy, clinical epidemiology