Matthew Might

Matthew Might, Ph.D., is a Professor and the inaugural Director of the Hugh Kaul Personalized Medicine Institute at the University of Alabama at Birmingham (UAB) School of Medicine. Previously, he served as a Presidential Scholar and Associate Professor at the University of Utah (Computer Science and Pharmaceutical Chemistry) and as a Visiting Professor at Harvard Medical School (Biomedical Informatics). His career bridges computational methods and biomedical research to advance precision medicine.

• Current Affiliation: UAB School of Medicine
• Prior Affiliations: University of Utah, Harvard Medical School
• Leadership: White House Precision Medicine Initiative appointee

Dr. Might's research focuses on precision medicine, leveraging computational approaches to personalize therapeutics for rare diseases. His work spans biomedical informatics, genetics, and computational biology, targeting conditions like neurodevelopmental disorders, diabetes subtypes, and cardiomyopathies.

Recent publications highlight trends in AI-driven diagnostics, rare disease modeling using zebrafish and iPSCs, and equity in genomic research. His team explores oxidative stress mechanisms, telehealth validation, and repurposing FDA-approved drugs through bioinformatic analysis.

Scientific contributions include appointment to the White House Precision Medicine Initiative by President Obama. He leads the Undiagnosed Diseases Network at UAB, integrating state-funded genomics and long-read sequencing to address diagnostic gaps.

Labs and teams include the UAB Center for Precision Animal Modeling and collaborations within the Undiagnosed Diseases Network, focusing on AI tools like mediKanren and Degree of Reading Difficulty for biomedical data.