Matthew Hirschey

Matthew Hirschey is an Associate Professor of Medicine, Pharmacology & Cancer Biology, and Cell Biology at Duke University. He is affiliated with the Duke Molecular Physiology Institute, Sarah Stedman Nutrition & Metabolism Center, and Duke Cancer Institute. His research focuses on metabolic control, mitochondrial signaling, and cellular processes in health and disease.

Education: Ph.D. from the University of California, Santa Barbara (2006). He has held multiple academic positions at Duke since 2011, progressing from Instructor to current roles as Associate Professor in multiple departments.

Research Interests: The Hirschey Lab explores metabolic pathways, mitochondrial signaling, and their roles in cancer, diabetes, and aging. Key areas include protein acylation, NAD+ metabolism, and metabolic reprogramming in tumors.

Grants: Recipient of NIH grants including the Endocrinology and Metabolism Training Program (2024–2029) and a project on breast cancer therapy (2024–2028). He mentors students in training programs like the Duke University Program in Environmental Health.

Awards: 2013 New Scholar in Aging Award from the Ellison Medical Foundation.

Labs/Teams: Leads the Hirschey Lab, collaborating with institutions like Duke-NUS and GenFlow Biosciences. Their work integrates biochemistry, data science, and imaging to uncover metabolic mechanisms.