معرفی
Dr. Matthew C. Trudeau is a Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. His research focuses on molecular physiology of ion channels, particularly hERG potassium channels and cyclic nucleotide-gated (CNG) channels. He earned his PhD at the University of Wisconsin-Madison under Dr. Gail Robertson and completed postdoctoral training with Dr. Bill Zagotta at the University of Washington and HHMI. Dr. Trudeau has held continuous NIH funding since 2004 and directs the T32 Training Program in Integrative Membrane Biology.
- University of Wisconsin-Madison (PhD, 1993-1998)
- University of Washington/HHMI (Postdoc, 1998-2004)
- University of Maryland (Assistant Professor 2004-present)
His work investigates how intracellular domains regulate ion channel gating, with emphasis on mechanisms underlying cardiac arrhythmias and inherited vision loss. Key discoveries include intersubunit interactions in CNG channels and molecular regulation of hERG deactivation by the eag domain. His lab employs molecular biology, electrophysiology, and fluorescence imaging to study these mechanisms.
Recent research trends focus on hERG channel subunit interactions (2022 textbook editorship), structural dynamics of KCNH channels (2021-2013), and therapeutic approaches to channelopathies (2015-2021 grants). His publications span high-impact journals like PNAS, Nature, and Journal of General Physiology.
- 2014 Paul F. Cranefield Award
- 2022 Co-Chair, Society of General Physiologists Meeting
- 2017-2018 NIH Special Emphasis Panel Member
- 2015-2016 Editorial Advisory Board, Journal of General Physiology
Dr. Trudeau's lab trains graduate students through NIH-funded programs and collaborates on multi-institutional research initiatives like M-CERSI. His work bridges fundamental biophysics with translational applications for inherited diseases.
