معرفی
Dr Matthew Belousoff is a Research Fellow in Drug Discovery Biology at Monash University. He specializes in structural biology, particularly using cryo-electron microscopy (cryoEM) to study G-protein coupled receptors (GPCRs) and antibiotic development. His work contributes to UN Sustainable Development Goals related to health and innovation. Belousoff has been involved in over 13 research projects, including structural characterization of GLP-1 receptors and GPCR heteromers, funded by the Australian Research Council and Monash University. He has authored/co-authored 80+ publications, focusing on GPCR dynamics, antibiotic resistance mechanisms, and peptide-receptor interactions.
Research Interests: Structural biology of GPCRs, cryoEM techniques, antibiotic development, and molecular pharmacology. His studies explore how cholesterol and lipid environments influence receptor activation, as well as designing non-peptidic agonists for therapeutic targets.
Recent Articles Highlight Trends in: CryoEM structural analysis of GPCRs in complex with ligands/G-proteins, lipid-dependent receptor activation mechanisms, and structural basis for antibiotic resistance. His work bridges fundamental biology with drug discovery applications.
Belousoff has been a Chief Investigator on multiple grants, including projects on GPCR heteromers and GLP-1R structural biology. He is part of the Monash Antimicrobial Resistance Group and collaborates internationally. Key media coverage includes discoveries on antibiotic resistance mechanisms.
Labs/Teams: Active in Prof. Patrick Sexton’s lab, focusing on GPCR structure-function relationships. Collaborates with teams at Monash and international institutions on cryoEM-based drug discovery.
