Matteo Minghetti

Matteo Minghetti is an Associate Professor in the Department of Integrative Biology at Oklahoma State University's College of Arts and Sciences. His research focuses on fish physiology and ecotoxicology, particularly investigating the toxicity and bioavailability of metals and emerging contaminants such as nanoparticles and microplastics in fish. He leads a research group that collaborates with environmental engineers and geologists to uncover toxicity mechanisms and develop alternative testing methods to reduce animal use in toxicity testing.

Dr. Minghetti obtained his PhD in Ecotoxicology from the University of Stirling in the United Kingdom in 2009 and completed his Laurea in Biotechnology from the University of Bologna, Italy in 2003. His postdoctoral training included research positions at the Swiss Federal Institute of Aquatic Science and Technology (Eawag), King's College London, and the University of Stirling, where he studied transcriptional regulation of lipid metabolism, primary gill cultures for environmental biomonitoring, and mechanisms of toxicity of metal nanoparticles.

His research program centers on developing and utilizing in vitro fish cell models (particularly RTgutGC and RTgill-W1 cell lines) to study metal toxicity, nanoparticle effects, microplastic interactions, and contaminant bioavailability. He has secured multiple significant grants including NIH, NSF, Alltech, and Alternatives Research & Development Foundation funding to support this work. His publications demonstrate a consistent focus on understanding how environmental conditions, such as chloride concentration, luminal composition, and plastic aging, influence metal speciation, bioavailability, and toxicity in fish systems.

Dr. Minghetti actively mentors students through undergraduate research, Niblack Research Scholars program, and graduate thesis/dissertation supervision. He teaches courses including Physiology, Environmental Physiology, and Chronicles of Extreme Physiology, emphasizing both human and comparative animal systems.