Matteo Allegretti

Matteo Allegretti is a researcher at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), part of the University of Cambridge. His work focuses on the molecular mechanisms governing nuclear shape and remodeling, particularly how defects in these processes contribute to diseases such as infertility, developmental disorders, and cancer metastasis.

• University: University of Cambridge
• Department: Medical Research Council Laboratory of Molecular Biology
• Research focus: Macromolecular complexes, nuclear envelope dynamics, structural biology

Allegretti employs advanced techniques integrating electron microscopy, light microscopy, and molecular modeling to study structural dynamics of nuclear proteins. His recent publications highlight discoveries in nuclear pore complex behavior, HIV-1 capsid transport, ATP synthase architecture, and nuclear envelope mechanics.

Key contributions include elucidating the role of mechanical forces in nuclear entry (2017), nuclear envelope rupture during cancer migration (2016), and structural adaptations of membrane proteins (2015, 2012). Collaborative work spans virology, bioenergetics, and mechanobiology.