Massimiliano Paganelli

Dr. Massimiliano Paganelli is an Assistant Clinical Professor in the Department of Pediatrics at the University of Montreal and a pediatric gastroenterologist/hepatologist at CHU Sainte-Justine. He leads the Hepatology and Cell Therapy Laboratory at the CHU Sainte-Justine Research Center.

• University of Rome 'La Sapienza' (MD)
• PhD in Hepatology and Cell Therapy at Université catholique de Louvain, Brussels

His research focuses on cell therapy for metabolic liver diseases using induced pluripotent stem (iPS) cells. Key areas include hepatocyte differentiation, creation of in vitro disease models, CRISPR/Cas9 mutation correction, and liver organoids for personalized medicine. He also investigates clinical pathologies like liver transplantation, neonatal cholestasis, hepatic encephalopathy, and chronic hepatitis B.

• Anti-CD20 treatment for hepatitis with autoimmune comorbidities
• Hemospray for esophageal bleeding in infants
• Sox9's role in stem cell differentiation
• HBV infection models using cord stem cells

Dr. Paganelli's work bridges clinical practice and translational research in pediatric hepatology, with emphasis on reducing reliance on liver transplants through autologous stem cell therapies.