Mary A Schuler

Mary A Schuler is a Professor in the Department of Cell and Developmental Biology at the University of Illinois at Urbana-Champaign, with affiliations in Biochemistry, Entomology, and Plant Biology. Her research focuses on molecular biology, biochemistry, and genomics of cytochrome P450 monooxygenases.

• B.A. and Ph.D. in Biochemistry from Cornell University
• Postdoctoral training at Washington University

Research Interests:
Dr. Schuler's work explores pre-mRNA processing and P450 monooxygenases, emphasizing their roles in:

• Plant defense toxin synthesis (e.g., Catharanthus roseus, Camptotheca acuminata)
• Insect detoxification of plant toxins and insecticides (e.g., Helicoverpa, Apis, Anopheles)
• Circadian regulation of P450 gene expression
• Structural modeling and biochemical characterization of P450 enzymes

Her publications highlight collaborations in computational modeling, heterologous expression systems, and evolutionary analyses of P450 families. Key projects include engineering alkaloid pathways in yeast/bacteria and studying P450 allelic variants in insecticide resistance.