معرفی
Prof. Martin Götte is a Professor in the Department of Gynaecology and Obstetrics at the University of Münster. His research focuses on extracellular matrix (ECM) components like proteoglycans and their roles in cancer metastasis, microRNA regulation of cell motility, tumor-stroma interactions, and 3D tumor modeling. He leads the Götte Lab, investigating mechanisms of cancer progression using advanced models including organoids and co-culture systems. His work bridges basic science with clinical applications, particularly in ovarian, breast, and endometrial cancers. Key projects include studying Syndecan family proteins' roles in radiation resistance, Musashi RNA-binding proteins' influence on therapy resistance, and TMEM230's impact on glycosylation in cancer and autoimmunity.
Research interests span molecular oncology, stem cell biology, and translational medicine. Notable contributions include identifying Syndecan-1 as a prognostic marker in breast cancer and developing 3D models to study invasive growth dynamics. His lab employs single-cell transcriptomics, nanoparticle technology, and in vitro systems to explore ECM-driven cancer mechanisms. Collaborations with the 'Cells in Motion' initiative and the Multiscale Imaging Centre enhance his multidisciplinary approach.
Publications emphasize clinical relevance, such as prognostic biomarker discovery and novel therapeutic strategies targeting ECM components or microRNA pathways. He actively participates in research networks addressing endometriosis, adenomyosis, and gynecologic malignancies. Funding sources include grants supporting his lab's innovative cancer modeling and drug delivery systems research.
