Markus Zweckstetter

Prof. Dr. Markus Zweckstetter is a Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Göttingen. His research focuses on understanding the structural basis of protein misfolding in neurodegenerative diseases such as Alzheimer's and Parkinson's, using high-resolution NMR spectroscopy combined with biochemical experiments and translational collaborations.

Key research areas include:

• Mechanisms of tau and alpha-synuclein aggregation
• Role of liquid-liquid phase separation in amyloid formation
• Structural characterization of disease-related protein conformations
• Investigations of molecular chaperone interactions (e.g., Hsp90)
• Structural analysis of diagnostic targets like TSPO

His work has provided groundbreaking insights into the structural polymorphism of tau, its interaction with microtubules and Hsp90, and the molecular pathways linking protein misfolding to neurodegeneration. Collaborations extend to cellular/animal models for therapeutic translation.