Markus Löbrich

Markus Löbrich is a Professor at the Technical University of Darmstadt, specializing in radiation biology and DNA repair mechanisms. His research focuses on understanding DNA damage responses, particularly in cancer cells and the long-term effects of radiation exposure. He leads studies on DNA repair pathways, including homologous recombination and non-homologous end-joining, and their implications for cancer therapy and radiation-induced health risks.

Key research areas include the identification of intrinsic radiosensitivity factors, mechanisms of chromosome aberrations, and the development of biological dosimetry tools for clinical radiation exposure assessments. Löbrich has contributed to preclinical models analyzing radiation effects in tissues and explored the impact of contrast media on DNA damage during CT imaging.

His work spans studies on pediatric cancer survivors, radiation-induced genetic instability, and the optimization of radiation protocols to minimize health risks. Collaborative projects include investigating DNA repair enzymes like POLθ and BRCA2, as well as tumor-specific radiosensitization strategies through targeted inhibition of Nek1 kinase.

Publications highlight advancements in automated DNA damage analysis (e.g., AutoFoci) and the biological consequences of radiation exposure in specific cell types, such as rod photoreceptors. Löbrich's research bridges basic science and clinical applications, aiming to enhance radiation safety and cancer treatment efficacy.