Mark Steven Joel Klempner

Mark Steven Joel Klempner is a Professor of Medicine at UMass Chan Medical School and the T.H. Chan School of Medicine. His research focuses on infectious diseases, immunology, and monoclonal antibody therapy for pathogens such as Lyme disease, Enterotoxigenic Escherichia coli (ETEC), and SARS-CoV-2. He has led studies on mucosal immunity, passive immunization, and vaccine development.

• Education: MD from Weill Cornell Graduate School of Medical Sciences.
• Key Affiliations: Faculty at UMass Chan Medical School and the Massachusetts Biological Laboratory.

His work emphasizes monoclonal antibody engineering for infectious diseases, including Lyme disease, ETEC, and rare viral infections. Recent publications highlight oral delivery systems and cross-reactive antibodies for broad protection. He collaborates with researchers like Yang Wang, Lisa Cavacini, and Celia Schiffer.

Key trends in his publications include preclinical models (nonhuman primates, mice), clinical trials, and translational research for infectious disease prevention. His lab at MassBiologics investigates immunoprophylaxis strategies and antibody stability.