Mark Jackson

Mark Jackson, PhD is a Professor in the Department of Pathology at the Case Western Reserve University School of Medicine. He serves as Vice Dean for Graduate Education, Director of the Cancer Biology Training Program, and a member of the Molecular Oncology Program at the Case Comprehensive Cancer Center. His academic journey includes a PhD from Wright State University (2001) and postdoctoral work at the Cleveland Clinic.

• Education:
  • PhD, Wright State University (2001)
  • BS, Kent State University (1996)
• Leadership Roles:
  • Vice Dean, Graduate Education
  • Director, Cancer Biology Training Program
  • Member, Case Comprehensive Cancer Center

His research focuses on tumor microenvironment, cancer immunology, and cellular transformation, with a key emphasis on the FAM83 protein family and their role in EGFR/RAS signaling. He also investigates immune checkpoint inhibitor resistance and molecular antagonism between Oncostatin M and Interferon-beta in regulating cancer stem cell reprogramming. Current projects aim to identify therapeutic targets and strategies for metastatic TNBC.

Recent publications highlight his work on tumor immunology and MAPK activation in stem-like programs. Collaborative clinical trials include studies on GRADE (glycemia reduction) and ASPREE (aspirin effects). His lab's VBIM methodology has uncovered novel oncogenes and resistance mechanisms.

Contact: mark.w.jackson@case.edu