Mark Andermann

Mark Andermann is Professor of Medicine at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, where he directs the Andermann Lab. His group investigates how motivational states—especially hunger—reshape sensory perception, learning, and memory through corticolimbic circuits.

Education & Appointments

No explicit educational history was provided in the source text.

Research Interests

• Motivational modulation of perception: Understanding how hunger and satiety gate the flow of food-related sensory information from retina to cortex to amygdala and hypothalamus.
• Two-photon calcium imaging & optogenetics: Chronic imaging of identified neurons and axonal boutons in behaving mice to dissect microcircuit logic.
• Neurobiology of obesity & eating disorders: Linking genetically-defined hypothalamic cell types to cortical value representations that drive feeding.
• Offline cortical reactivation: Examining how quiet-waking reactivation of motivationally-salient cue representations influences circuit connectivity.

Publication Landscape

Between 2003 and 2025 Andermann has co-authored over 70 papers. The most recent work (2023–2025) clusters around four themes:

1. Choroid plexus-immune interactions in neuroinflammation and hydrocephalus.
2. Stochastic neuropeptide and dopaminergic control of satiation and mating.
3. Long-timescale cortical reactivations underlying memory consolidation.
4. Single-cell and spatial transcriptomic brain atlases.

Collaborations & Funding Narrative

Active collaborations include:

• Brad Lowell laboratory (BIDMC): Hypothalamic cell-type-specific manipulations during behavioral tasks.
• Chinfei Chen (Boston Children’s Hospital): Retino-thalamic wiring logic.

Grant details were not listed in the provided text, but the sustained high-output publication record and resource-intensive techniques (chronic two-photon imaging, custom endoscopes, transcriptomic atlases) indicate substantial NIH/NINDS or similar funding.

Laboratory & Resources

The Andermann Lab occupies Center for Life Sciences, Room 701 at BIDMC (3 Blackfan Circle, Boston MA 02115). Core technologies include:

• Two-photon resonant scanning microscopes for large-scale calcium imaging in behaving mice.
• Multiplexed optical recording of neuromodulatory sensors (MORE endoscope).
• Optetrode and fiber-photometry rigs for simultaneous optogenetic stimulation and recording.
• Custom computational pipelines for high-dimensional neural and transcriptomic datasets.