معرفی
Marie Flamand is a research group leader in the Structural Virology Laboratory at the Institut Pasteur in Paris. Her work focuses on understanding the pathogenesis of arboviruses such as dengue, Zika, and Rift Valley fever viruses, with a particular emphasis on the role of accessory proteins like NS1 and NSm in viral virulence and immune modulation.
- Institution: Institut Pasteur
- Research Unit: Structural Virology Lab
- Research Focus: Arboviruses, Viral Pathogenesis, NS1 Protein Function
Her research has led to major advances in dengue diagnostics, including the development of a gold-standard NS1 antigen detection kit. Her team discovered that secreted NS1 forms pro-inflammatory complexes with HDL, contributing to severe dengue manifestations. She leads the ongoing project Viral toxins, studying the biological effects of dengue NS1.
The recent publications reflect a strong focus on flavivirus biology, structural interactions, host immune responses, and emerging viral threats. The work spans molecular virology, structural biology, immunopathology, and translational diagnostics, with increasing attention to systemic inflammation and host-lipoprotein interactions during infection.
- Key Publications in: EMBO Reports, Journal of Virology, Clinical Infectious Diseases, Emerging Microbes & Infections
- Recent Trends: NS1-HDL complex formation, cytokine storm mechanisms, viral diagnostics, host genetic factors in infection
Marie Flamand has not received any explicitly mentioned scientific awards in the provided text. However, her sustained leadership and high-impact publications indicate significant recognition in the field of virology.
She has supervised or collaborated on multiple research projects and publications but no specific students are listed. She has been involved in collaborative research across disciplines, including structural biology, immunology, and emerging infectious diseases. There is no mention of external grant funding in the provided texts, but her active projects suggest ongoing support.
Her research is conducted within the Structural Virology Lab at the Institut Pasteur, a leading institution in infectious disease research. This lab provides a collaborative environment integrating structural, biochemical, and cellular approaches to study virus-host interactions.
