معرفی
Margaret Phillips is a tenured Professor and Chair of the Department of Biochemistry at UT Southwestern Medical Center, with a secondary appointment in Pharmacology. She holds the Sam G. Winstead and F. Andrew Bell Distinguished Chair in Biochemistry. Her research focuses on biochemistry and drug discovery targeting parasitic protozoa, particularly malaria (Plasmodium falciparum) and African sleeping sickness (Trypanosoma brucei). Her work emphasizes polyamine and nucleotide biosynthesis pathways as drug targets.
- Educations:
- B.S. in Biochemistry, University of California, Davis (1981)
- Ph.D. in Pharmaceutical Chemistry, University of California, San Francisco (1988)
- Postdoctoral Fellow at UCSF Department of Biochemistry (1988–1992)
Research interests include developing novel inhibitors of pyrimidine and polyamine biosynthesis pathways, with a focus on antimalarial and antitrypanosomal drug discovery. Her lab collaborates globally to advance chemical probes and clinical candidates, such as the dihydroorotate dehydrogenase inhibitor DSM265. Key contributions include understanding resistance mechanisms and optimizing drug candidates for efficacy and selectivity.
- Grants & Collaborations:
- Collaborations with institutions like NIH, Medicines for Malaria Venture, and academic partners worldwide
Her lab (Phillips Lab) is part of the Biophysics and Biological Chemistry Graduate Programs at UT Southwestern, fostering interdisciplinary research in neglected tropical diseases.
