Margaret Hostetter

Margaret Hostetter is an Adjunct Professor at Yale University's School of Medicine, serving as Physician-in-Chief at Yale-New Haven Children's Hospital and Chair of the Department of Pediatrics since 2002. She leads the Yale Child Health Research Center and specializes in pediatric infectious diseases, particularly Candida albicans and Streptococcus pneumoniae. Her research focuses on fungal pathogenesis, biofilm formation, and mechanisms of host invasion. Hostetter holds five patents and has received prestigious awards including membership in the National Academy of Sciences' Institute of Medicine.

Education:

• Fellowship: Boston Children's Hospital, Harvard (1980)
• Residency/Internship: Boston Children's Hospital, Harvard (1978)

Research Interests: Hostetter’s work explores Candida albicans pathogenesis, including adhesion, biofilm inhibition (e.g., via statins), and interactions with the gastrointestinal tract. Her lab investigates mitochondrial proteome roles in fungal morphogenesis and E-cadherin cleavage mechanisms disrupting intestinal barriers.

Grants & Activities:

• Program Director, NIH-funded Pediatric Scientist Development Program
• NIH Peer Review Member (2008–2011)
• Former Chair, Division of Pediatric Infectious Diseases, University of Minnesota

Awards:

• E. Mead Johnson Award for Pediatric Research
• Institute of Medicine Membership (2001)
• NIH Blue Ribbon Panel Appointment (2003)

Labs/Teams: Directs the Yale Child Health Research Center, focusing on translational pediatric research and mentoring physician-scientists.