معرفی
Dr. Marcus G. Pezzolesi serves as an Assistant Professor of Internal Medicine in the Division of Nephrology and Hypertension and Diabetes and Metabolism Center at the University of Utah School of Medicine, with an adjunct appointment in Human Genetics. His dual appointments position him at the intersection of clinical nephrology and genetic research in diabetes complications.
His educational trajectory includes:
- BS from University of Massachusetts Amherst
- Graduate Certificate from Northeastern University
- PhD in Biological Sciences (Human Genetics focus) from The Ohio State University
- MPH in Quantitative Methods from Harvard School of Public Health
- Postdoctoral Research Fellowship at Joslin Diabetes Center/Harvard Medical School
Dr. Pezzolesi's research centers on genetic and molecular mechanisms of diabetic kidney disease, with emphasis on biomarker discovery for end-stage renal disease prediction. His work integrates genomics, epigenetics, and proteomics to identify genetic modifiers, circulating miRNAs, and protein signatures that drive kidney failure in diabetes. Recent publications demonstrate leadership in multi-omics approaches and international consortia.
Analysis of his 15 most recent publications (2019-2025) reveals consistent focus on molecular predictors of diabetic kidney failure, particularly through genome-wide association studies, miRNA profiling, and metabolomic analyses. His work increasingly incorporates machine learning for risk stratification while maintaining strong clinical epidemiology foundations.
As an active member of the University of Utah's Diabetes and Metabolism Center, Dr. Pezzolesi collaborates with major consortia including SUMMIT, GENIE, and DCCT/EDIC. His research program receives substantial NIH funding for longitudinal studies of diabetic nephropathy progression, though specific grant details aren't provided in this source.
He maintains laboratory operations within the Diabetes and Metabolism Center, directing molecular analyses of patient cohorts and developing protocols for circulating biomarker quantification. Current projects focus on preanalytical variables in miRNA measurement and ceramide-mediated lipotoxicity pathways in renal cortex damage.
