Marco Guarnacci

Marco Guarnacci is a Research Fellow at The Australian National University (ANU), affiliated with the John Curtin School of Medical Research and the ANU College of Science and Medicine. He is a member of the Shine-Dalgarno Centre for RNA Innovation and the Division of Genome Sciences and Cancer, working within The Preiss Group - RNA Biology. His research focuses on RNA epigenetics, specifically investigating RNA modifications such as m6A and m5C, their roles in mRNA stability, translation, and cancer biology.

Guarnacci’s work explores the functional implications of RNA methylation in cellular processes, with recent studies examining the co-occurrence of m6A and m5C modifications at single-molecule resolution and the clinical relevance of NSUN7 methylation in liver cancer. He has contributed to methodological advancements like target-specific profiling of m5C using amplicon sequencing.

His research interests include enzymatic mechanisms of RNA modifications, transcriptome-wide analysis, and the interplay between epigenetic changes and disease. While no formal awards are listed, his publications demonstrate significant contributions to RNA biology and cancer epigenetics. Guarnacci is actively involved in supervising research students and collaborates widely within the ANU network and internationally.

Key affiliations include the ANU Researcher Portal and ORCID profile, with ongoing projects in RNA innovation and cancer epigenetics. His work bridges basic molecular mechanisms with translational applications in diagnostics and therapy.