Marc Ribo Panosa

Marc Ribo Panosa is a Professor in the Department of Biology at the University of Girona, specializing in Biochemistry and Molecular Biology. He is a member of the Protein Engineering Research Group, where his work integrates biophysics, molecular biology, and protein engineering to investigate the structure-function relationships of proteins, particularly cytotoxic ribonucleases.

His research focuses on two main areas: protein structure, stability, and folding under temperature and pressure; and the molecular mechanisms underlying the cytotoxic activity of ribonucleases such as onconase and human pancreatic ribonuclease. He employs techniques including UV, CD, NMR, and X-ray crystallography, combined with protein engineering, to characterize unfolding pathways, transition states, and oligomerization processes.

More recently, his work has expanded into advanced protein modification technologies like expressed protein ligation (EPL) and protein trans-splicing (PTS), enabling site-specific incorporation of unnatural amino acids and post-translational modifications. These methods allow for precise functional analysis of proteins and offer potential for developing tunable therapeutic agents.

The publication trends reflect a strong focus on structural and mechanistic biochemistry, with applications in cancer therapy, antimicrobial design, and protein function control in vivo.

• ORCID: 0000-0001-6944-6383

He has participated in multiple research projects and scientific conferences, contributing to fundamental knowledge in protein science. While specific student advisees are not listed, his leadership in a research group indicates mentorship and team-based investigation. His work holds promise for future applications in drug design and functional proteomics.

He is associated with the research group Protein Engineering Research Group, where he leads investigations into protein engineering and functional modulation using cutting-edge biochemical and biophysical techniques.