معرفی
Manuel R. Amieva is a Professor at Stanford University School of Medicine, holding joint appointments in Pediatrics - Infectious Diseases and Microbiology & Immunology. He is also a member of the Maternal & Child Health Research Institute (MCHRI). His clinical practice at Stanford Medicine Children's Health focuses on pediatric infectious diseases.
- Education:
- Medical Education: Stanford University School of Medicine (1997)
- Fellowship: Stanford University Pediatric Infectious Disease Fellowship (2004)
- Internship & Residency: Stanford Health Care at Lucile Packard Children's Hospital (1998-1999)
Dr. Amieva's research investigates host-pathogen interactions at epithelial barriers, with specific expertise in Helicobacter pylori, Listeria monocytogenes, Salmonella enterica, and Staphylococcus aureus. His lab develops innovative organoid culture systems with controlled polarity to study microbial colonization and oncogenic mechanisms. Key discoveries include:
- H. pylori's manipulation of epithelial junctions via the CagA protein
- Listeria's exploitation of cell extrusion sites for invasion
- Staphylococcus toxin interactions with adherens junctions
- Gastric stem cell activation by pathogens
Recent publication trends show continued leadership in infectious disease mechanisms (2020-2025), with a focus on:
- Pathogen-specific epithelial breach strategies
- Organoid modeling of viral/bacterial interactions
- Redox-dependent host factor regulation
- Single-cell spatial transcriptomic analyses
- Multi-institutional educational frameworks
His scientific collaborations span disciplines including:
- Gastric cancer genomics initiatives
- COVID-19 lung infection models
- Stem cell-microbe interactions
- Medical education reform projects
Dr. Amieva maintains active clinical research while mentoring students in both the Microbiology & Immunology and Pediatrics programs. His lab at Stanford employs advanced 3D confocal microscopy and organ-on-a-chip technologies to visualize epithelial colonization dynamics.
