Manisha Tripathi

Manisha Tripathi, Ph.D. is an Assistant Professor in the Department of Cell Biology and Biochemistry at Texas Tech University Health Sciences Center School of Medicine. She obtained her Ph.D. in Cancer Biology from Vanderbilt University.

• Research Focus: Investigates tumor-stromal interactions in prostate cancer, particularly:
• Reciprocal signaling between cancer cells and Cancer-Associated Fibroblasts (CAFs)/Tumor-Associated Macrophages (TAMs)
• Role of TBX2 signaling in therapeutic resistance
• Exosomal microRNA mechanisms in bone metastasis
• Immune microenvironment modulation of drug efficacy

Research Trends: Recent publications emphasize:

• TBX2-driven receptor switching in CRPC
• Exosomal miRNA regulation of metastasis
• TIAM1/Rac1 in prostatic development
• Immune microenvironment biomarkers
• Stromal epigenetic alterations
• Novel therapeutic targeting strategies

Scientific Awards & Grants:

• NIH R01 CA233796
• NIH R01 CA272985
• NIH R21 CA253402
• Department of Defense Prostate Cancer Research Program Award
• TTUHSC President's Distinguished Scholar Award

Laboratory Focus: Uses advanced models including 3-D cultures, xenografts, transgenic mice, and patient-derived systems to study tumor-stromal communication for improved prostate cancer therapies.