Malin Winerdal

Malin Winerdal is a Researcher at Karolinska Institutet's Department of Laboratory Medicine, affiliated with the Division of Clinical Immunology and the Peter Bergman Research Group (AMP-group). Her work focuses on clinical immunology with emphasis on primary immunodeficiency, innate immunity, antimicrobial peptides, and cancer immunology.

Her academic background includes:

• Doctor of Philosophy (PhD), Department of Medicine, Solna (2015)
• University Medical Degree (2008)

Dr. Winerdal's research centers on immune mechanisms in urinary bladder cancer, particularly regulatory T cells and B cell interactions within the tumor microenvironment. She investigates how neoadjuvant chemotherapy modulates antitumor immunity, the role of FOXP3 in Treg functionality, and pathways of immune suppression like ICAM-1/TGFβ2-mediated perforin inhibition. Her work extends to neonatal brain injury and adenosine receptor signaling in hypertension, demonstrating a multidisciplinary approach to immunological mechanisms across disease contexts. Using techniques including flow cytometry, epigenetic analysis, and murine models, she bridges basic science with clinical applications in immunology.

Analysis of her 15 most recent publications (2008-2021) reveals a dominant focus on bladder cancer immunology (75% of articles), with recurring themes of T cell regulation, tumor microenvironment dynamics, and immune checkpoint mechanisms. Secondary research streams include neonatal neuroprotection (13%) and cardiovascular immunology (12%), showcasing methodological versatility across in vitro, murine, and clinical human studies. Her collaborative work consistently involves Karolinska Institutet's urology and immunology departments, with Peter Bergman and Ola Winqvist as frequent co-investigators.

She actively contributes to the AMP-group's mission of investigating innate immunity and antimicrobial peptides in primary immunodeficiencies, participating in both basic research and clinical outreach initiatives within Karolinska Institutet's immunology division.