Maike Frye

Dr. Maike Frye is a researcher at the Institute of Clinical Chemistry and Laboratory Medicine within the University Medical Center Hamburg-Eppendorf (UKE), holding a Doctor of Natural Sciences (Dr. rer. nat.) degree. Her work bridges clinical chemistry and vascular pathophysiology with significant contributions to understanding thrombosis, inflammation, and lymphatic biology.

Her research portfolio centers on hemostasis-thrombosis mechanisms, vascular biology (particularly lymphatic and blood vessel systems), and immune responses in infection and metabolic disease. Key investigations include Factor XII's role in bacterial trapping, NET formation dynamics in sepsis, cGMP signaling in platelet biomechanics, and lymphatic junctional maturation. Her publications reveal a strong focus on molecular pathways like NO-GC/cGMP and Notch signaling, with implications for therapeutic development in cardiovascular and inflammatory disorders.

Associated with the Vascular Biology Lab at UKE, her work employs advanced methodologies including stent flow chamber systems and molecular imaging. Recent publications demonstrate translational relevance across sepsis management, stent technology, and lymphatic disease mechanisms, highlighting her integrative approach to vascular pathophysiology.