معرفی
Mahima Swamy is a Principal Investigator and Wellcome Trust Sir Henry Dale Fellow at the University of Dundee's MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU). Her research focuses on immune interactions at the intestinal epithelium, particularly the role of intraepithelial lymphocytes (IEL) in maintaining homeostasis and resisting infections. She leads a team exploring how IEL coordinate responses to dietary, microbial, and chemical inputs, with implications for inflammatory bowel diseases (IBD) like Crohn’s and Coeliac disease.
Education: B.Tech in Biological Sciences from Birla Institute of Technology and Science (BITS), Pilani, India. PhD in Immunobiology at the Max Planck Institute of Immunobiology in Freiburg, Germany. Postdoctoral training at Cancer Research UK (London) and the University of Dundee, funded by EMBO and Marie-Curie fellowships.
Research Interests:
- Regulation of IEL function via PIM kinases and LRRK2.
- Metabolic adaptations of IEL to the gut environment.
- Mechanisms of immune dysregulation in IBD.
- Cross-talk between IEL and intestinal epithelial cells.
Lab Techniques:
- Proteomics and phospho-proteomics.
- Mouse models of infection and inflammation.
- Epithelial organoid:IEL co-cultures.
- Single-cell phosphoprotein analysis.
Awards:
- Wellcome Trust Sir Henry Dale Fellowship (2017).
Collaborations:
- Joint projects with the Alessi lab investigating LRRK2 in IBD.
- Active member of Tayside Immunology and Society for Mucosal Immunology.
Current lab members include postdocs (Amanpreet Chawla, Purbasha Bhattacharya) and PhD students (Rebecca Pemberton, Neema Skariah).
