Madhukar Trivedi

Madhukar Trivedi is a Professor of Psychiatry at UT Southwestern Medical Center, where he serves as Chief of the Division of Mood Disorders and Director of the Center for Depression Research and Clinical Care. He holds the Betty Jo Hay Distinguished Chair in Mental Health and Julie K. Hersh Chair for Depression Research.

• Education: MBBS and MS from Baroda, India; Psychiatry residencies in Baroda and Detroit; Fellowship at UT Southwestern
• Professional Affiliations: American College of Neuropsychopharmacology (ACNP), American Psychiatric Association (APA), American Society of Clinical Psychopharmacology (ASCP), and others

His research focuses on:

• Neurobiological mechanisms of depression and bipolar disorder
• Development of treatment algorithms for treatment-resistant depression
• Biomarker discovery for precision medicine in mood disorders
• Integration of machine learning with clinical data
• Public health approaches to youth mental health via TX-YDSRN and T-RAD

Recent publications highlight:

• Neuroimaging-based prediction of antidepressant response (EMBARC, T-RAD)
• Digital therapeutics for youth depression (CT-152, MIRAI trial)
• Immune-metabolic interactions in depression
• Machine learning models for treatment personalization
• Pharmacological interventions for stimulant use disorder

Scientific recognition includes:

• Gerald Klerman Senior Investigator Award
• Multiple years as Clarivate Analytics Highly Cited Researcher
• Leadership roles as American Journal of Psychiatry Deputy Editor and ASCP President

Key initiatives:

• Established EMBARC (precision psychiatry) and TX-YDSRN (youth mental health)
• Developed standardized tools like CHRT-SR9 for suicide risk assessment
• Conducted NIH-funded trials including STAR*D and CO-MED