Maciek R. Antoniewicz

Professor Maciek R. Antoniewicz is a faculty member in the Department of Chemical Engineering at the University of Michigan. He leads the Antoniewicz Laboratory for Metabolic Engineering and Systems Biology, which develops next-generation tools and techniques for analyzing, engineering and manipulating microbial and mammalian systems applied to specific problems in biotechnology and medicine.

Dr. Antoniewicz's research focuses on metabolic engineering, biotechnology, cancer metabolism, and microbial communities. His laboratory makes use of modern techniques for cell culture, 13C metabolic flux analysis, mass spectrometry, molecular biology, bioinformatics and computational biology. Current research interests include elucidating syntrophic interactions in microbial communities, analysis of compartment-specific fluxes in mammalian cells, dynamic flux analysis, cancer metabolism, and engineering microbes for enhanced utilization of renewable substrates and production of value-added chemicals.

His recent publications demonstrate a strong trend toward developing and applying metabolic flux analysis techniques across diverse biological systems, from microbial communities to cancer cells. The work spans fundamental methodology development to applied biotechnology problems, with particular emphasis on 13C metabolic flux analysis and systems-level understanding of cellular metabolism.

Dr. Antoniewicz has received numerous prestigious awards including:

• Elected Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2018
• National Academy of Engineering (NAE) US-EU, Frontiers of Engineering Participant, 2017
• Biotechnology and Bioengineering Daniel I.C. Wang Award, 2015
• Gerard J. Mangone Best Young Scholar Award, 2012
• NSF CAREER Award, 2011
• DuPont Young Professor Award, 2008
• James E. Bailey Young Investigator Award in Metabolic Engineering, 2008

Dr. Antoniewicz has advised numerous PhD and Master's students who have gone on to win awards and secure prestigious positions. His research has been supported by significant grants from NSF, DOE, and other agencies, including a recent $1.5M DoE grant to study microbiomes with Professors Lin and Allman. He has also received grants to study fatty acid metabolism and dipeptide metabolism in CHO cells.

The Antoniewicz Laboratory maintains state-of-the-art facilities for both microbial and mammalian cell culture, including advanced mass spectrometry equipment for metabolic flux analysis. The laboratory is equipped with multiple bioreactor systems, cell culture facilities, and analytical instruments that support cutting-edge research in metabolic engineering and systems biology.