معرفی
Lynn Zechiedrich is a Professor and the Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology at Baylor College of Medicine. She holds dual appointments in the Department of Biochemistry & Molecular Pharmacology and the Dan L Duncan Comprehensive Cancer Center. Her research focuses on DNA topology, antibiotic resistance mechanisms, and the development of non-viral gene therapy vectors. Zechiedrich earned her PhD from Vanderbilt University and BS from the University of Arkansas, with postdoctoral training at UC Berkeley.
Her work bridges molecular biophysics and microbiology, investigating how DNA supercoiling influences biological processes and therapeutic applications. Notably, she pioneered the use of supercoiled minicircle DNA for gene therapy, enhancing delivery efficiency. Zechiedrich has received prestigious awards, including AAAS and National Academy of Inventors fellowships, and mentors students through grants like the NIH R35 GM141793.
Research interests include understanding topoisomerase interactions, bacterial resistance pathways, and structural biology of DNA. Her lab collaborates widely, with funding from NIH and NSF to study DNA damage recognition and supercoiling's role in gene regulation. Zechiedrich’s contributions to education were recognized with the 2020 Presidential Award for Excellence in Education.
Her >150 publications span high-impact journals like Science and Nucleic Acids Research, addressing topics from gyrase mechanisms to respiratory virus immunity. She actively contributes to professional societies and serves on editorial boards, advancing both basic science and translational medicine.
