Lukas Schrangl

Lukas Schrangl is a Researcher at the Institute of Biophysics within the Department of Natural Sciences and Sustainable Resources at the University of Natural Resources and Life Sciences, Vienna (BOKU). His work focuses on biophysical techniques to study molecular interactions, particularly in immunological contexts.

His educational background includes a doctoral degree, with his thesis "Quantifying conformational dynamics of biomolecules via single-molecule FRET" completed in 2020. His research spans experimental physics, light optical microscopy, and biophysics, with strong emphasis on software development and data science applications in biophysical research.

Schrangl's research interests center on single-molecule FRET techniques to investigate T-cell receptor-ligand interactions and molecular force measurements. His work bridges biophysics, immunology, and computational methods, developing innovative approaches to quantify receptor-ligand interaction times and forces at the molecular level. He has created several open-source software tools including the sdt-python package and fret-tester to advance analysis capabilities in single-molecule biophysics.

His publication record shows consistent high-impact output from 2017 through 2025, with recent work focusing on synaptic force shielding in T cell receptor interactions and advanced quantification of receptor-ligand interaction lifetimes. His research demonstrates strong interdisciplinary connections between physics, biology, and computational science.

Schrangl actively presents his work at major conferences, including the 69th Annual Meeting of the Biophysical Society (2025) and the Biophysics Austria Conference (2024), demonstrating ongoing engagement with the international scientific community.

His technical expertise spans both experimental biophysics and computational methods, making significant contributions to the development of quantitative approaches for studying molecular interactions in immunological contexts.