Lucas Wange

Dr. Lucas Wange is a Post-Doc Researcher at the Comparative Genomics Group led by Tomàs Marquès Bonet at Pompeu Fabra University. His research focuses on the evolution of gene regulation across vertebrates, utilizing high-throughput sequencing techniques such as mcSCRB-seq2. He specializes in evolutionary genomics, epigenetics, and comparative analyses of genomic sequences.

His work explores topics like the role of genes (e.g., TRNP1) in brain evolution, mechanisms of cancer (e.g., AML) and lymphoma, and cross-kingdom interactions involving fungal pathogens. He has contributed to methodological advancements in single-cell RNA sequencing and CRISPR-based screens for therapeutic target identification.

Recent research highlights include studies on immune surveillance in lymphoma, epigenetic modulation in atherosclerosis, and synergistic drug effects in leukemia. His findings bridge evolutionary biology with translational medicine, particularly in cancer biology and genomic technologies.

Lucas collaborates on projects involving PDX mouse models, CRISPR screens, and functional genomics. His lab is part of the Institut de Biologia Evolutiva, emphasizing interdisciplinary approaches to genomic and evolutionary questions.