Lisa Wills

Lisa Wills serves as Assistant Professor of Computer Science at Duke University's Trinity College of Arts & Sciences and holds a joint appointment in Electrical and Computer Engineering at the Pratt School of Engineering since 2019. Her research bridges computer architecture and domain-specific applications, with a focus on hardware acceleration for computationally intensive fields.

Dr. Wills earned her Ph.D. from Columbia University in 2014. Her academic journey reflects a deep commitment to advancing hardware-software co-design methodologies for real-world computational challenges.

Her research centers on developing efficient hardware accelerators for big data analytics, particularly in genomics, graph processing, and database systems. She pioneers frameworks that simplify accelerator deployment while tackling critical bottlenecks in genomic data analysis, protein structure prediction, and privacy-preserving computing. Current work focuses on hardware-aware machine learning systems and energy-efficient architectures for emerging AI applications.

Analysis of her publication record reveals a clear trajectory: from foundational work in database processing units (2014-2016) to specialized genomic accelerators (2019-2021), then evolving toward ML-enhanced design automation (2022-2023) and cutting-edge architectural abstractions (2024-2025). Her research consistently targets the intersection of hardware efficiency and domain-specific computational demands, with increasing emphasis on AI/ML workloads.

• Google ML and Systems Junior Faculty Award (2025)

Dr. Wills actively mentors doctoral students including Chris Kjellqvist (lead architect of Beethoven accelerator framework), Mason Ma (PyTFHE FHE framework), and Mansi Choudhary (COCOSSim accelerator simulator). Her research is supported by significant grants including the NSF AI Institute: Athena ($20M, 2021-2027), Meta-funded ProSE accelerator project (2023-2026), and NSF CAREER award (2021-2026), totaling over $25M in active funding.

She directs the APEX Lab (Application-driven Programmable Efficient Accelerated Systems), which develops open-source frameworks like Beethoven for FPGA/ASIC accelerator deployment and focuses on lowering barriers for non-hardware researchers to leverage custom acceleration in genomics, AI, and big data applications.