Linnea M. Baudhuin

Linnea M. Baudhuin, Ph.D., FACMG, is Professor of Laboratory Medicine and Pathology at Mayo Clinic, Rochester, serving as Consultant in the Division of Laboratory Genetics and Genomics and Department of Clinical Genomics. Her work pioneers genomic medicine applications in cardiovascular and renal inherited disorders, dyslipidemias, and advanced genomic testing.

Education

• Ph.D. in Clinical Chemistry, Cleveland State University/Cleveland Clinic Foundation (2002)
• Residency in Clinical Molecular Genetics, Mayo Clinic College of Medicine (2005)
• Postdoctoral Fellowship in Clinical Molecular Genetics, Mayo Clinic College of Medicine (2005)
• Postdoctoral Fellowship in Clinical Chemistry, Mayo Clinic College of Medicine (2003)
• B.S. in Biology, University of Wisconsin-Oshkosh (1995)

Research Focus: Dr. Baudhuin investigates genotype-phenotype relationships in aortopathies (including Marfan syndrome via FBN1 curation), cardiomyopathies, familial hypercholesterolemia, and sudden cardiac death. Her ClinGen leadership develops variant classification guidelines, while pharmacogenomics work includes the TAILOR-PCI antiplatelet therapy trial. She integrates AI in genomic diagnostics and optimizes LDLR variant characterization for precision treatment.

Scientific Recognition

• 2023: Athena Society Honorary Member
• 2019-2017: Four-time Clinical Chemist Recognition Award recipient
• 2017: American College of Medical Genetics and Genomics Fellow
• 2015: University of Wisconsin-Oshkosh Distinguished Alumni
• 2011: Outstanding Young Investigator Award

Leadership & Grants: As TAILOR-PCI co-investigator, she advances pharmacogenomics implementation. She chairs Mayo Clinic's Hereditary Cardiovascular Subdiscipline and leads ClinGen's Cardiovascular Postmortem Genomic Odyssey Board. Her NIH-funded work includes ClinGen variant curation panels for FBN1 and cardiomyopathy genes.

Research Ecosystem: Directs Mayo's Hereditary Renal Subdiscipline, co-leads Cardiovascular Disease Oriented Group, and participates in Ehlers-Danlos Syndrome and Aneurysm Forums. Integrates with Mayo Center for Individualized Medicine's Bioinformatics Executive Committee and Clinomics Genomic Odyssey Board for translational innovation.