Linda M. Randolph

Linda M. Randolph, MD, is a Clinical Associate Professor in the Department of Pediatrics at the University of Southern California (USC). Her work focuses on medical genetics, neonatal care, and pediatric genetic disorders. She is affiliated with Children’s Hospital Los Angeles (CHLA), where she contributes to clinical and translational research in areas such as genetic diagnostics, prenatal screening, and the management of congenital disorders.

Her research emphasizes leveraging genomic technologies—such as exome sequencing and deep learning—for early diagnosis and treatment of conditions like mucopolysaccharidosis, mitochondrial disorders, and neurofibromatosis. She has also investigated chimerism in twins and the clinical implications of genetic variants in pediatric populations.

Key contributions include studies on the economic evaluation of early exome sequencing, the application of machine learning in facial dysmorphology analysis, and the correlation between genetic mutations and clinical phenotypes. Her work bridges basic science and clinical practice to improve outcomes for children with rare genetic conditions.

Dr. Randolph’s publications span over two decades, reflecting her sustained engagement in pediatric genetics, prenatal diagnosis, and the intersection of genetic medicine with emerging technologies. She has collaborated on projects addressing thalassemia management, twin discordance, and the teratogenic effects of medications.