Lin-Feng Chen

Lin-Feng Chen is a Professor in the Department of Biochemistry at the University of Illinois. His research focuses on epigenetic regulation of NF-κB signaling in immunity and cancer, H. pylori-induced gastric disease, and the role of Brd4 in innate immunity. He holds affiliations with the Carl R. Woese Institute for Genomic Biology.

Education:

• B.S., Xiamen University, China (1987)
• M.S., Peking Union Medical University (1990)
• Ph.D., Kyoto University, Japan (1999)
• Postdoctoral, Gladstone Institute of Immunology and Virology, UCSF (1999–2003)

Research Interests:

• Epigenetic modulation of NF-κB in inflammation and cancer
• Host-pathogen interactions, particularly with H. pylori
• Role of Brd4 in macrophage biology and metabolic diseases
• Chromatin remodeling and post-translational modifications

Recent Research Trends: His work emphasizes the interplay between epigenetic regulators (e.g., Brd4, ASH1L) and inflammatory pathways, with applications in cancer therapy and metabolic disorders. Key findings include Brd4’s role in H. pylori-induced inflammation and its inhibition as a therapeutic target.

Labs/Teams: Leads a lab investigating NF-κB signaling, host-pathogen interactions, and epigenetic regulation at the Carl R. Woese Institute for Genomic Biology.