معرفی
Lei Duan is an Associate Professor in the Department of Anatomy & Cell Biology at Rush University Medical Center. His primary affiliation is with Rush Medical College. Dr. Duan's research focuses on understanding molecular mechanisms of cancer therapy resistance, particularly in breast and lung cancers. He holds an MD from Shanghai Jiaotong University Medical School, China. His laboratory investigates prolyl peptidases' role in endocrine therapy resistance in ER+ breast cancer and targets such as MCL1 and Aurora kinases in small cell lung cancer.
His work integrates basic and translational research, collaborating with Carl Maki, PhD. Key areas include autophagy regulation, PI3K/AKT/mTOR signaling, and epigenetic modifications (e.g., histone demethylases). He has over 70 peer-reviewed publications and maintains active collaborations with institutions like NIH and Scopus. His lab is part of the Cell & Molecular Medicine Research Division at Rush.
Notable projects involve developing biomarkers for therapy sensitivity and studying RTK signaling pathways. Dr. Duan's work bridges mechanistic discoveries with potential clinical applications in oncology.
